P2X7 receptor deletion or inhibition improves behavioral changes in certain neurological diseases, such as Alzheimer’s disease, Huntington’s disease, and stress conditions (Díaz-Hernández et al., 2009; Iwata et al., 2016; Farooq et al., 2018; Martin et al., 2019). The gene discussed is P2RX7; the disease is juvenile Huntington disease.