P2RX7 and Sepsis: The P2X7 receptor activation is involved in chemokine (C-X-C motif) ligand 1 (CXCL1) recruitment and brain endothelial activation, which promotes blood-brain barrier (BBB) leakage and microglial cell activation, causing neuroinflammation in the acute phase of sepsis (24 h) (Wang et al., 2015).