We found that Iba1 and GFAP were upregulated in WT septic mice, whereas P2X7−/− septic mice prevented this event in the cerebral cortex, indicating that the absence of the P2X7 receptor may be involved in the reversal GFAP and Iba-1 upregulation during sepsis. The gene discussed is P2RX7; the disease is Sepsis.