NFKB1 and neoplasm: Annelise et al., demonstrated that the anti-tumor immunity of necroptosis depended on the induction of NF-κB mediated by protein kinases RIPK1 and RIPK3, while Tania et al., believed that the immunogenicity was related to the release of damps, rather than NF-κB (Aaes et al., 2016; Snyder et al., 2019).