Cis-diamminedichloroplatinum (better known as cisplatin or CDDP) is a platinum drug that is widely used for treatment of malignant tumors and exhibits significant therapeutic effects against testicular germ cell, colorectal, ovarian, bladder, lung, and head and neck cancers (Galanski, 2006; Ghosh, 2019); however, it differs from OXA in the levels of CRT exposure it induces, and cannot activate PERK-dependent eIF2α phosphorylation (Martins et al., 2011). This evidence concerns the gene EIF2A and cancer.