After activation, DRP1 combines with Fission1 (Fis1) and mitochondrial fission factor (Mff) to mediate the metabolic disorder of cells and inhibit glutathione in mitochondria to weaken the ability of free radical scavenging, further increase mitochondrial reactive oxygen species (mtROS), thus up-regulating the level of NLRP3 protein and producing IL-1β, cause pyroptosis, and eventually cause ischemic damage to neurons (Park et al., 2018; Kleele et al., 2021). The gene discussed is MFF; the disease is Other metabolic disease.