Moreover, the inhibition of ERβ/MAPK/ERK pathway abolished E2 inhibition of the cell viability, colony formation capability and migration of HCC cells, suggesting that E2 suppressed HCC by activating NLRP3 inflammasome via ERβ/MAPK/ERK pathway (Wei et al., 2015). The gene discussed is NLRP3; the disease is hepatocellular carcinoma.