Summarily, it can be deduced that SHD activates NLRP3 inflammasome through promting ROS release and inhibiting NF-κB signal pathway to induce apoptosis and cell cycle arrest of HCC cells in vitro and in vivo, which need to be further confirmed by using the inhibitor of NF-κB signal pathway (Dai et al., 2022). This evidence concerns the gene NFKB1 and hepatocellular carcinoma.