Bingling Dai and others studied the role and mechanism of SHD and NLRP3 inflammasome in HCC, and the results showed that two ingredients of SHD, Oldenlandia and OP (Oldenlandia 15 g: Prunella spike 1.5 g = 10:1), significantly inhibited the growth of HCC cells and xenograft tumors evidenced by the decreased size and weight of tumour, and downregulated Ki67. Here, NLRP3 is linked to hepatocellular carcinoma.