It has been reported that SHD plays an anti-tumor role through suppressing the growth of tumor cells and promoting the apoptosis of tumor cells, and strengthens the immunity (Zhu et al., 2018; Wang et al., 2019a; Ge et al., 2019; Luo et al., 2020; Zhao et al., 2020). The gene discussed is SHD; the disease is neoplasm.