CNTNAP2 and epilepsy: This evidence is in line with several studies carried out in several experimental models of ASD-epilepsy (Cntnap2, En2, Fmr1, Nrp2), in which defects of GABAA receptor-mediated neurotransmission have been related to the pathogenesis of ASD-epilepsy comorbidity (Bozzi et al., 2018).