It was found that AML cells were associated with overexpression of CD33/TIM3 and CLL1/TIM3 as compared to normal tissues when analyzing the density of CD33, CD123, TIM3, among other antigens, on AML bulk and LSCs at initial diagnosis and relapse (Haubner et al., 2019). This evidence concerns the gene HAVCR2 and acute myeloid leukemia.