In addition, we found that the expression of HDAC1 and HDAC2 in the lupus tubulointerstitium tissue was significantly negatively correlated with the GFR of patients (R2 = 0.8172, p = 0.0052, and R2 = 0.8651, p = 0.0024 respectively, Supplementary Figures S3C, 3E). This evidence concerns the gene HDAC1 and systemic lupus erythematosus.