CCND2 and neoplasm: As an example, it has been demonstrated that endothelial cell-derived exosomal miR-503, which is increased after neoadjuvant chemotherapy, can impair tumor growth, invasion, and proliferation in BC by inhibiting the expression of cyclin D2- and D3-encoding genes (CCND2 and CCND3) (Bovy et al., 2015).