To further clarify how M1/M2 cardiac macrophage change after MI and whether VSIG4 is explicitly expressed in M2 macrophages or also expressed and has functions in M1 macrophages, we performed Western blot assays in the sham-operated group, on days 3-7 after MI, and showed that VSIG4 was significantly highly expressed in myocardial tissue on day 7 of the infarction (Figure S2A). Here, VSIG4 is linked to myocardial infarction.