VEGFA and breast cancer: Liu et, al. discovered that after subcutaneously injecting 4T1 BC cells into the mammary glands of mice, the expression of VEGF increased and the production of prostaglandin E2 (PGE2) was induced in the microvascular endothelial cells of the lung tissues of mouse, which enhance vascular hyperpermeability, upregulate endothelial adhesion molecules, and tumor cells homing 17.