CCDC24 and neoplasm: 53. NETs have critical roles in cancer metastasis. By binding to CCDC24, the chromatin DNA component in NETs is considered a chemotactic factor for tumor cell recruitment 54. The NETs-related proteases can split the laminin protein, one of the ECM components, to cause laminin remodeling and regulate integrin-mediated signaling in tumor cells, promoting tumor cell proliferation 15. The accumulation of NETs promotes the establishment of lung PMN, in which more tumor cells are trapped and colonized in the lung. Therefore, BC is more likely to metastasize to lung tissues 53.