In this model system, Txnip depletion was effective without affecting Gm15441 (Figure 8B, C) and recapitulated results found in young mice with MCD-induced NASH with regard to effects on expression of CHOP and its downstream targets as well apoptosis and macrophage infiltration (Figure 8C-E). This evidence concerns the gene DDIT3 and metabolic dysfunction-associated steatohepatitis.