In their study, they used Txnip whole body KO mice which lost the exon two to exon eight of Txnip. Md Kaimul Ahsan et al. also reported that TXNIP (alternative name: TPB-2) plays a pathogenic role in MCD diet induced NASH mouse model, and inhibitors of TXNIP can be used for the prevention or treatment of NASH 31. Here, TXNIP is linked to metabolic dysfunction-associated steatohepatitis.