SOD1 and amyotrophic lateral sclerosis: Another mouse model study (30) indicated that ALS-prone Sod1 transgenic (Sod1-Tg) mice exhibit significant mitigation of the decrease in intestinal motility as a result of improvement of the intestinal flora: specifically, Akkermansia muciniphila (AM) was found to alleviate symptoms of ALS, whereas Ruminococcus torques and Parabacteroides distasonis were found to exacerbate them.