MALAT1 and neoplasm: Up-regulated tumor-promoting lncRNAs such as MALAT1, UCA1, H19, HIF1A-AS2 and down-regulated tumor suppressor lncRNAs such as NBAT1, GASS, RNCR3, etc., all of which play an important role in the formation and malignant progression of gliomas (16, 17).