Up-regulated tumor-promoting lncRNAs such as MALAT1, UCA1, H19, HIF1A-AS2 and down-regulated tumor suppressor lncRNAs such as NBAT1, GASS, RNCR3, etc., all of which play an important role in the formation and malignant progression of gliomas (16, 17). Here, HIF1A is linked to neoplasm.