Genetic studies have associated the Reelin gene (RELN) with a number of psychiatric diseases, including schizophrenia, bipolar disorder, and autism spectrum disorder (Impagnatiello et al., 1998; Fatemi et al., 2001, 2005; Persico et al., 2001; Grayson et al., 2005; Ovadia and Shifman, 2011; Wang et al., 2014; Baek et al., 2015; Lammert and Howell, 2016). The gene discussed is RELN; the disease is bipolar disorder.