RELN and bipolar disorder: This link is supported by several studies showing that Reelin levels are reduced in patients with schizophrenia, bipolar disorder, and autism spectrum disorder (Impagnatiello et al., 1998; Fatemi et al., 2000, 2001, 2005; Persico et al., 2001; Grayson et al., 2005; Torrey et al., 2005; Ruzicka et al., 2007; Ovadia and Shifman, 2011; Wang et al., 2014; Baek et al., 2015; Lammert and Howell, 2016).