Furthermore, Reelin also regulates adult neurogenesis and synaptogenesis (Kim et al., 2002; Pujadas et al., 2010; Teixeira et al., 2012; Bosch et al., 2016), whose disruption is considered to be involved in the pathogenesis of psychiatric disorders (Kempermann, 2008; Zhao et al., 2008). Here, RELN is linked to psychiatric disorder.