RELN and Cognitive impairment: In fact, Reelin haploinsufficiency models, based on the suppression or reduction of Reelin expression (or its downstream pathway), manifest features related to neuropsychiatric disorders, such as cognitive impairments, psychosis vulnerability, and learning deficits that frequently coexist with evident alterations in hippocampal plasticity (Tueting et al., 1999; Krueger et al., 2006; Marrone et al., 2006; Qiu et al., 2006a; Ammassari-Teule et al., 2009; Folsom and Fatemi, 2013).