CD8A and neoplasm: Topotecan, Teniposide, and etoposide, which are topoisomerase inhibitors, can cause replication fork collision and abnormal DNA activation, leading to the activation of STING signaling and its downstream NF-κB and type I IFN pathways in a cGAS-dependent or independent manner, thereby promoting the infiltration of DCs and CD8+ T lymphocytes and inhibiting tumor growth (35, 123–125).