STINGVAX, the first STING-based cancer vaccine designed using granulocyte–macrophage colony-stimulating factor (GM-CSF)-secreting cancer cells and CDNs, has been found to induce a superior antitumor response in vivo compared to unformulated GM-CSF-secreting tumor cell vaccines in models of CT26 colon cancer, upper gastrointestinal squamous cell carcinoma (SCCFVII), and pancreatic cancer (PANC02) (113). This evidence concerns the gene CSF2 and familial pancreatic carcinoma.