Similarly, treatment with increasing concentrations of T-DM1 and infection with MOI 0.01 of VSVΔ51-Fluc led to a significant enhancement in viral output 48 hpi from 4T1.2-HER2 and 4T1.2-HER2T cells in a dose-responsive fashion, with no viral enhancement observed with T-DM1 in parental 4T1.2 cells (Figure 5H). This evidence concerns the gene ERBB2 and infection.