CD8A and neoplasm: In early-stage tumours (D7), CD8+ TILs were predominantly PD-1-TIM-3-, but as tumours progressed, there was a decrease in the proportion of PD-1-TIM-3- cells (37→20%) and a concomitant increase in the proportion of terminally exhausted PD-1+TIM-3+ cells (19→59%; Figure 8D).