Bulk CD8+ TILs from D14 and D21 tumours were heterogeneous in their expression of both PD-1 and TIM-3, while virtually all p15E-reactive CD8+ TILs were PD-1+ (>99% in both D14 and D21 tumours) with a subset of these cells co-expressing TIM-3 (Figures 10D, E). This evidence concerns the gene HAVCR2 and neoplasm.