CD4 and neoplasm: TEM cells were the predominant population throughout the course of tumour outgrowth (>63% and >52% of total CD4+ and CD8+ TILs, respectively), but early-stage tumours (D7) exhibited substantial infiltration by naïve CD44LOCD62L+ TN cells (24% and 25% of total CD4+ and CD8+ TILs, respectively; Figures 6A, B).