Notably, decreases in the ratios of CD4+/CD8+, CD4+FoxP3+/T-bet+CD8+ and CD4+T-bet+/CD4+FoxP3+ TILs were observed during progressive tumour outgrowth, suggesting that the T cell infiltrate in MC38 tumours shifts toward a more pro-inflammatory composition during progressive outgrowth. This evidence concerns the gene CD4 and neoplasm.