Upon intestinal mucosal injury, I-FABP is released from epithelial cells into the circulating blood, and levels of plasma I-FABP have been reported to correlate with the severity of intestinal disease [e.g., ulcerative colitis, Crohn’s disease (CD), mesenteric ischemia, coeliac disease], and is considered a marker of intestinal epithelial cell tight junction disruption and cell death (103–107). The gene discussed is FABP2; the disease is ulcerative colitis.