Both COVID-19 and AOSD are characterized by common inflammatory pathways, macrophages shift from anti-inflammatory M2 to pro-inflammatory M1, and the production of pro-inflammatory mediators, including IL-6, IL-1β, and TNF‐α, to modulate the local immune responses sometimes developing to the so-called “cytokine storm” syndrome (8, 9). This evidence concerns the gene IL1B and COVID-19.