To compare more globally the changes triggered by the four lead BiXAbsTM and the respective 1MAbs and 2MAbs on ErbB/AKT/ERK signaling, we used two phosphoproteomic arrays that included ~90 RTKs and downstream kinases to determine the whole phosphoproteomic profiles in three pancreatic cancer cell lines. This evidence concerns the gene EGFR and pancreatic neoplasm.