Data obtained in the three pancreatic cancer cell lines (Figure 4C) revealed decreased expression of EGFR, HER2 and HER3 (comparable profiles in all cell lines) upon incubation with BiXAbTM and 2MAbs, except for the 2MAbs 3Patri+1Cetu that led to increased HER2 expression in BxPC3 and C-PDX P4604 cells, unlike the BiXAbTM 3Patri-1Cetu-Fc. The gene discussed is EGFR; the disease is familial pancreatic carcinoma.