These four BiXAbsTM (i) displayed EC50 affinity values to their cognate receptor quite similar (1-3 fold) to those of the parental 1MAbs (Figure 1D), (ii) were among the strongest inhibitors of EGF/NRG1-induced phosphorylation of AKT and ERK (Figure 2A), (iii) were among the most efficient in reducing cell viability (Figure 2B), and (iv) were strong ADCC inducers (Figure 2C) in pancreatic cancer cell lines. Here, AKT1 is linked to pancreatic neoplasm.