Among them, genes associated with splicing mutations in adult IBD include CARD9, CUL2, IL12RB1, MSH2, NCF4, and NOD2. In pediatric IBD, they include ANKZF1, CD40LG, CTLA4, IL10RA, IL10RB, IL12RB1, NCF4, NOD2, SKIV2L, STXBP3, TTC37, TTC7A, and WAS (Figure 3, Table 3). This evidence concerns the gene SKIC2 and inflammatory bowel disease.