In the signaling pathway, some genes are involved in the NOD-like receptor signaling pathway, Toll-like receptor signaling pathway, and JAK-STAT signaling pathway connected with CD, including CARD9, NOD2, and IL12RB1, whereas IL10RA and IL10RB are involved in the JAK-STAT signaling pathway connected with UC (Figure 2). The gene discussed is NOD2; the disease is Cowden disease.