Among them, genes associated with splicing mutations in adult IBD include CARD9, CUL2, IL12RB1, MSH2, NCF4, and NOD2. In pediatric IBD, they include ANKZF1, CD40LG, CTLA4, IL10RA, IL10RB, IL12RB1, NCF4, NOD2, SKIV2L, STXBP3, TTC37, TTC7A, and WAS (Figure 3, Table 3). The gene discussed is NOD2; the disease is inflammatory bowel disease.