Approximately, 20 splicing mutations in 13 genes (ANKZF1, CD40LG, CTLA4, IL10RA, IL10RB, IL12RB1, NCF4, NOD2, SKIV2L, STXBP3, TTC37, TTC7A, and WAS) have been reported to be associated with IBD in children (Table 3). Here, NOD2 is linked to inflammatory bowel disease.