Approximately, 20 splicing mutations in 13 genes (ANKZF1, CD40LG, CTLA4, IL10RA, IL10RB, IL12RB1, NCF4, NOD2, SKIV2L, STXBP3, TTC37, TTC7A, and WAS) have been reported to be associated with IBD in children (Table 3). The gene discussed is ANKZF1; the disease is inflammatory bowel disease.