XBP1 and inflammatory bowel disease: Another study evaluated mRNA splicing for transcription factor X-box binding protein-1 (XBP1) by quantitative reverse transcriptase real-time PCR to measure relative expression of Th1, Th17, and Treg cytokines, finding that mRNA splicing for transcription factor XBP1 may be involved in immunopathogenesis of IBD (17).