Additional experimentation demonstrated that whereas the TFH-like cells arising in these studies, including those arising in mice carrying Prdm1-deficient T-cells, have TFH-like function but not immunoregulatory properties, their IL-10-producing TR1-like counterparts have profound immunoregulatory properties in an experimental encephalomyelitis (EAE) model (5). The gene discussed is IL10; the disease is encephalomyelitis.