Despite its importance in viral clearance, the precise role of IFN during COVID-19 has still not been elucidated; IFN-I production can be partially impaired by SARS-CoV-2 proteins such as the M protein or non-structural proteins nsp1, nsp6, nsp13-15 and orf6 (49–51). Here, IFNA1 is linked to COVID-19.