ADSL and infection: Relish can directly trigger miR-317 production to target PGRP-LC in addition to AMPs, so generating a negative feedback loop that facilitates to restoration of immune homeostasis during the activation of the IMD pathway in Drosophila. Mechanically, in Drosophila, during the infection of Gram-positive bacteria (E. coli) stimulate various gene expression, in particular, the Dpt, in which expression levels is increased at 3 h and reach a peak at 12 h.