Hodgkin lymphoma (HL), a rare and potentially curable B-cell malignancy, is known to have a highly inflammatory microenvironment and to produce different types of cytokines: IL-15 and its receptor complex are aberrantly expressed, and IL-15 is secreted by the malignant cells and acts as an anti-apoptotic factor in HL and a mitogen through the phosphorylation of STAT5, and ERK1/2 (75). This evidence concerns the gene IL15 and Hodgkins lymphoma.