However, in our previously used SplD-induced asthma model, where C57BL/6 mice also presented a stronger eosinophilic response than BALB/c mice, the neutrophilic response was negligibly weak, and still IL-33 was processed in a comparable way to the here shown Alt-induced allergic airway inflammation model, which underlines the importance of mast cell proteases in the regulation of IL-33 (22). The gene discussed is IL33; the disease is asthma.