In our model, we repeatedly exposed mice to Alt extract as an in vivo mouse model of allergic IL-33-dependent airway inflammation, because Alt triggers the airway epithelium resulting in the release of alarmins, including ATP, IL-33, and TSLP, which induce ILC2 proliferation and a type 2-driven immune response (4, 44). The gene discussed is TSLP; the disease is inflammatory response.