Strikingly, mice harboring intestinal Rgs1-/- OT-I TRM cells displayed significantly higher Lm-OVA titers in mLN, spleen, and liver than those with OT-I Rgs1+/+ TRM cells, thus, demonstrating that the absence of Rgs1 in intestinal CD8+ TRM cells diminishes their capacity to control the systemic spreading of Lm-OVA upon local re-infection (Figure 6B). Here, CD8A is linked to infection.