The underrepresentation of intestinal OT-I Rgs1-/- cells was also seen following a systemic infection of mice with LCMV-OVA where at day 8 post infection (i.p.)with LCMV-OVA; the OT-I Rgs1-/- cells were present in significantly lower frequencies in the small intestinal IEL and LPL compartment (Supplementary Figure 5). The gene discussed is RGS1; the disease is infection.