It remains to be investigated whether the known genetic association between RGS1 SNP’s and mainly T cell-mediated pathologies including multiple sclerosis (71, 72), celiac disease (73, 74), and type 1 diabetes (73, 74), can be linked to aberrant TRM cell formation, described here in the genetic absence of Rgs1 in antigen-specific CD8 T cells. The gene discussed is CD8A; the disease is multiple sclerosis.