Following intestinal infection (i.g.)with Lm-OVA infection the absence of Rgs1 generally did not impact the expression pattern of the other Rgs family members early, and late after intestinal Lm-OVA infection, except for Rgs10 which on day 8 post Lm-OVA infection was up-regulated in small intestinal OT-I Rgs1-/- IEL, but not in OT-I Rgs1-/- LPL (Supplementary Figure 3D). The gene discussed is PITX2; the disease is digestive system infectious disorder.