IL5 and Pruritus: After comparing the changes in clinical scores, we found that the decrease in CCL17/TARC, CD25, and IL-5 was positively related to the improvement of SCORAD, EASI, and (or) Pruritus-NRS, particularly CCL17/TARC, which showed the strongest correlation with the change of clinical scores (r = 0.47, P = 0.006 with SCORAD; r = 0.53, P = 0.002 with EASI; r = 0.47, P = 0.006 with Pruritus-NRS; Figure 4D).