In our data, some clusters are patient dependent and also some adipocyte differentiation state, such as clusters 2 and 3 in macrophages, and in Figure 6B, state 3 is patient 53 specific, so we removed the data of patient 53 and obtained the similar results that we observed the marked increase in the proportions of both MARCO+PLAUR+, LAMs, AECs, LECs and FIPs (data were unshown), indicating the enhanced pro-tumor functions and inflammatory phenotype in breast cancer adjacent adipose tissues. The gene discussed is PLAUR; the disease is breast cancer.