TNF and neoplasm: Platelet-DC interactions also promote the over expression of co-stimulatory molecules on DCs and increase the production of cytokines such as TNF-α, IL-12, and IL-6.These cytokines promote the maturation of DCs to target T lymphocyte antigens that help activate type I helper T-cells (TH1 cells) and CD8+ T-cells to kill tumor cells (220).