When platelets are activated, it can not only release PDGF-BB to promotes the upregulation of VEGFgeneexpression in vascular ECs, but also directly releases VEGF promoting the proliferation, differentiation, and migration of vascular ECs, enhances the permeability of vascular ECs, promotes neovascularization, provides oxygen and nutrients to ischemic and hypoxic tissues, and causes the rapid growth of tumor cells (7, 294, 295). Here, VEGFA is linked to neoplasm.