Furthermore, TRIB3 is implicated in the carcinogenesis of a variety of cancers, with evidence indicating that it could inhibit the degradation of FOXO1 and enhance SOX2 transcription, thus contributing to the carcinogenesis of breast cancer (60) and induction of immune evasion by inhibiting the STAT1–CXCL10 axis and impeding the CD8+ T cell infiltration in colorectal cancer (61). Here, SOX2 is linked to colorectal cancer.