Overexpression of CaM and CaMKIIɑ blocked the rescue of cognitive decline and neurodegeneration induced by miR-193b-3p and miR-152-3p, respectively, which was associated with activation of the downstream p38/NF-κB and Bcl-2/Bax/caspase-3/PARP pathways. The gene discussed is NFKB1; the disease is Mental deterioration.