High mortality (65-85%), severe hepatic failure, multiple organ failure, encephalopathy, increased intracranial pressure (ICP), cerebral edema, neuropsychiatric disorders (confusion, disorientation, coma), systemic inflammatory response, body temperature increased, upper right pain parts of the abdomen, bloated abdomen (ascites), nausea, vomiting, drowsiness, breath may have a musty or sweet smell, convulsions, hypoglycaemia, hyperbilirubinemia, jaundice, coagulopathy (decreased factor V activity and prolonged prothrombin time). This evidence concerns the gene F2 and liver failure.