However, it has been found that pulmonary vascular sclerosis activates two relevant transcriptional co-activators of the Hippo signaling pathway, YAP/TAZ, early in PAH, and subsequently YAP/TAZ (Yes-Associated Protein/Transcriptional co-activator with PDZ-binding motif) activates glutaminase enzymes that promote glutamine metabolism and mesenchymal responses, leading to changes in the extracellular environment, such as macrophage recruitment, which in turn leads to PAH (107, 108). Here, GLS is linked to pulmonary arterial hypertension.