ACE2 and pulmonary arterial hypertension: In addition, during the SARS-CoV-2 virus pandemic a few years ago, it was shown that the angiotensin-converting enzyme-2 (ACE2) receptor mediates the entry of three coronavirus strains: SARS-CoV, NL63 and SARS-CoV-2, which triggers cardiovascular disease and severe lung injury and exacerbates the PAH process (139).