Consistently, KLF4-deficient macrophages displayed increased pro-inflammatory cytokine expression, and myeloid-specific KLF4 deficiency predisposed mice to diet-induced obesity, glucose intolerance, and IR (150), indicating a crucial role for KLF4 in regulating macrophage polarization and maintenance of adipose tissue homeostasis. Here, KLF4 is linked to obesity due to melanocortin 4 receptor deficiency.