In summary, these results indicate that mucosal delivery of Ad-HA/NP+Ad-IL-1β increased HA-specific IgG and IgA titers in serum and nasal swabs, and IgG responses in BAL, while pH1N1 infection resulted in higher IgA pH1N1 responses in serum, BAL, and nasal swabs. The gene discussed is CD79A; the disease is infection.