PTGS2 and neoplasm: Figure 6B shows the multifaceted view of nude mouse liver and HE staining of metastatic tumor sections. We used the hepatic replacement area (HRA) to assess the severity of liver metastasis. The results showed that the inhibition of NETs with Dnase-1 during liver metastasis formation could lead to a significant decrease in HRA compared to the control. After the COX-2 knockdown in HGC-27 cells, we discovered the HRA was further reduced (Figure 6C).