Several clinical and experimental studies have revealed that the Chikungunya virus (CHIKV) infection leads to the profound production of pro-inflammatory cytokines and chemokines such as tumor necrosis factor (TNF), interleukin (IL)-6, 4, 1β and 12 in human as well as in mouse macrophages via p38 and Jun N-terminal protein kinase (JNK)-mitogen-activated protein kinase (MAPK) mediated pathway, which may aggravate host immune system towards CHIKV infection mediated fever (CHIKF) and polyarthralgia (19–22). This evidence concerns the gene TNF and Fever.