With further exploration on the role of LRP1 by bioinformatic analysis, our study showed significant impact of LRP1 expression on the activities of angiogenesis, collagen formation and degradation, EMT and inflammatory signature, indicating that LRP1 expressing CAFs and macrophages played a critical role in regulating the stromal and immune remodeling in BLCA. The gene discussed is LRP1; the disease is bladder transitional cell carcinoma.