Efforts have been made to boost and prolong the efficacy, including in vitro enriching memory phenotype T cells through culturing CAR-T cells with PI3K inhibitors (5), combination of γ-secretase inhibitor to increase the BCMA expression on the surface of MM cells (6) and “armed” CAR-T cells to transform an immune-suppressive signal into an immune-stimulatory signal (7). Here, TNFRSF17 is linked to Miyoshi myopathy.