Based on correlations analyses between CRGs and ICGs (Figure 8 and Supplementary Figure 4), we selected three CRGs (PRNP and SNCA [unfavorable for prognosis] and COX17 [favorable for prognosis]) that had more significant correlations with ICGs than other CRGs for further validation in HCC samples; the clinical characteristics of patients are shown in Table 1. This evidence concerns the gene COX17 and hepatocellular carcinoma.