Although IDH1 mutation, 1p/19q co-deletion status (27), and several other predictive signatures associated with inflammation (28), ferroptosis, cuproptosis, necroptosis, and N6-methyladenine methylation (29) have been identified in gliomas, these ingredients are not enough to overpower the quandary of treatment and prognosis in glioma. Here, IDH1 is linked to glioma.