Although IDH1 mutation, 1p/19q co-deletion status (27), and several other predictive signatures associated with inflammation (28), ferroptosis, cuproptosis, necroptosis, and N6-methyladenine methylation (29) have been identified in gliomas, these ingredients are not enough to overpower the quandary of treatment and prognosis in glioma. Here, IDH1 is linked to central nervous system cancer.