In glioma, the majority of ICD-associated genes were up-regulated, including BAX, IL17RA, MYD88, ENTPD1, IFNGR1, ATG5, CALR, P2RX7, EIF2AK3, PIK3CA, IL1B, TNF, NLRP3, NT5E, TLR4, CD4, LY96, and FOXP3 (Figure 2B). Here, ATG5 is linked to central nervous system cancer.