In glioma, the majority of ICD-associated genes were up-regulated, including BAX, IL17RA, MYD88, ENTPD1, IFNGR1, ATG5, CALR, P2RX7, EIF2AK3, PIK3CA, IL1B, TNF, NLRP3, NT5E, TLR4, CD4, LY96, and FOXP3 (Figure 2B). This evidence concerns the gene CALR and central nervous system cancer.