IL4R and Increased total eosinophil count: Stimulation of theairways with allergens increases the local IL5 concentration, which correlateswith the severity of airway eosinophilia, while IL4RA codes for the αchain of the IL4 receptor, which can bind IL4 and IL13 to regulate the IgEproduction [4, 16, 21, 23, 34,35, 36, 37, 38, 39,40];