It has been shown that alteredexpression of some of these genes may cause bronchoconstriction of the airwaysand hyperresponsiveness to bronchoconstricting agents such as histamine,increased vascular permeability, edema, eosinophilia and neutrophilia, smoothmuscle cell proliferation, collagen deposition and fibrosis in different tissueareas, mucin secretion by goblet cells, metaplasia of goblet cells, andhypertrophic changes in the respiratory epithelium [16, 20, 42];. The gene discussed is MUC5AC; the disease is Increased total eosinophil count.