Using the low-density lipoprotein receptor knockout (LDLRo) atherosclerosis mouse model, BM donor mice were fed a high-fat diet to induce atherosclerosis and orally inoculated with Porphyromonas gingivalis (Pg), a keystone periodontal pathogen; the second group was sham-inoculated. The gene discussed is LDLR; the disease is atherosclerosis.