As opposed to a fall n hippocampal sirtuin-1 and sirtuin-3, chronic stress reportedly increases sirtuin-1 in nucleus accumbens, and both pharmacological sirtuin-1 activation or sirtuin-1 overexpression within this region increases depression- and anxiety-like behaviours, while sirtuin-1 antagonist infusion counters these changes (240). This evidence concerns the gene SIRT1 and major depressive disorder.