Renal hemodynamics changes, overactive of the renin-angiotensin-aldosterone system (RAAS), oxidative stress, and inflammation processes are the major established mechanisms involved in the pathogenesis of DKD, and renal fibrosis is the final common pathway (Fang Q. et al., 2021; Lin et al., 2018; Samsu, 2021; Zhang et al., 2022). This evidence concerns the gene REN and diabetic kidney disease.