AGT and Hyperglycemia: Uremic toxins and hyperglycemia could promote the production of angiotensin II (Ang-II), the most important components of RAS, which in turn induces renal vasoconstriction and glomerular hyperfiltration, inflammatory and profibrotic factors secretion, extracellular matrix deposition, as well as morphological changes of podocytes, accelerating the progression of DKD (Chi et al., 2021; Lu et al., 2020; Lu et al., 2018; Tanase et al., 2020).