The TLRs family member, especially TLR2 and TLR4, have been demonstrated to activate inflammatory process, such as NF-κB signaling pathway, and play a critical role in promoting tubular inflammation in DKD (Du et al., 2013; Gluba et al., 2010; Lin et al., 2013; Lin et al., 2012; Mosterd et al., 2021; Mudaliar et al., 2014; Tang and Yiu, 2020). The gene discussed is NFKB1; the disease is diabetic kidney disease.