Activation of the NOD-like receptors (NLRs) family members, especially NOD2 and nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3), have also been proved to exert a crucial effect on the progression of DKD (Du et al., 2013; Fernandes et al., 2019; Lv et al., 2022). Here, NOD2 is linked to diabetic kidney disease.