Indeed, high-fat-diet-induced insulin resistance in rodents is associated with increased markers of mitophagy (Ehrlicher et al., 2021), while ablation of the key mitophagy regulating protein FUNDC1 within skeletal muscle does not impair mitochondrial bioenergetics or induce insulin resistance within this tissue (Fu et al., 2018). The gene discussed is INS; the disease is Insulin resistance.