In support of this, research in murine models indicate that inhibition of reactive lipid synthesis protects against high-fat diet-induced insulin resistance (Ussher et al., 2010; Kurek et al., 2015), while pharmacological (Anderson et al., 2009) and genetic (Lee et al., 2010; Boden et al., 2012) inhibition of mitochondrial ROS emission preserves insulin sensitivity. Here, INS is linked to Insulin resistance.