For instance, exosomal lncRNAs such as LNMAT2 (lymph node metastasis associated transcript 2), MALAT1, Gm26809 and NEAT1 etc. have been involved in metabolic reprogramming of tumor microenvironment (Sun et al., 2018), macrophage polarization and inflammatory diseases (Liu R. et al., 2018). The gene discussed is LINC00858; the disease is neoplasm.