Moreover, immunoprecipitation studies in CD8+ T cells isolated from TB patients showed lncRNA-CD244 interacted with chromatin modification enzyme enhancer of zeste homolog 2 (EZH2) (Figure 4A), which catalyzed H3K27me3 at promoters of IFN-γ and TNF-α to inhibit their production (Wang et al., 2015). The gene discussed is CD8A; the disease is tuberculosis.