The genes involved in the development of NAFLD, are related to the regulation of lipid metabolism in the liver and include patatin-like phospholipase domain-containing protein 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), glucokinase regulatory protein (GCKR), membrane bound O-acyltransferase domain containing 7 (MBOAT7) and hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13)24. Here, TM6SF2 is linked to metabolic dysfunction-associated steatotic liver disease.