In the study, receiver operator characteristic (ROC) curve showed that the area under the ROC curve (AUC), sensitivity, and specificity of sPD‐L1 in distinguishing HBV‐HCC from HBV‐LC were 0.645, 47.3%,78.8%, respectively (Figure 1E), and the cutoff vale was 156.38 pg/mL. Here, SPDL1 is linked to hepatocellular carcinoma.